In insulin-resistant populations, several adipokines, such as leptin and adiponectin, as well as muscle contraction-induced factors, so-called myokines (i.e., IL-6), have been shown to modulate insulin resistance and inflammatory status [ 143].
Around 80% of obese people are insulin resistant, and insulin resistance precedes type 2 diabetes.
In insulin resistant states, β cells attempt to compensate for the resistance by secreting more insulin.
The objective of this study is to evaluate the anti-insulin resistance bioactivity of 16 selected traditional Chinese medicinal plants in DXMS-induced IR (insulin resistant) HepG2 cells.
In a previous study using rodent adipocytes, we characterized and quantified the secretome and glycome during insulin sensitive and insulin resistant conditions induced by indirectly (HG + INS) or directly (LG + PUGNAc) modulating O-GlcNAc levels.
Our results demonstrate that in an insulin resistant model (db/db) when the extracts are used with insulin (complementary therapy), the plant extracts tend to modulate glucose better than controls, while in ob/ob mice this effect is not seen.
Many scientists think that the tendency to become insulin resistant is genetic.
We classified two groups (insulin sensitive or insulin resistant).
Insulin action in the liver of insulin resistant mice was restored significantly with APS administration.
