Previous study has demonstrated that SHP-1 regulates glucose homeostasis by modulating insulin signaling and insulin clearance in the liver.
Further, ZnT8 deficient mice and humans with the Trp325Arg ZnT8 variant exhibit increased insulin clearance.
However, whole-body insulin clearance was greater in women than men.
CEACAM1-mediated IR internalization and degradation is important for insulin clearance in the liver (Poy et al., 2002b).
Leptin has been shown to be able to modulate insulin secretion.
Whole-body insulin clearance was measured during a pancreatic clamp study (somatostatin to inhibit islet hormone secretion) including 13 adults (6 men); and whole-body insulin clearance was measured during a euglycemic, hyperinsulinemic clamp study including 27 adults (13 men).
The lower C-peptide/insulin molar ratio in AA suggests that they probably have lower hepatic insulin clearance than Caucasian children.
Splanchnic insulin extraction is greater in men, indicating that greater peripheral insulin clearance in women accounts for the sex differences we observed.
To investigate the effect of raloxifene on insulin sensitivity, β-cell function, hepatic insulin clearance, and glucose tolerance in postmenopausal women.
Fasting insulin clearance was calculated as CP0/I0 with CP0 = fasting C-peptide, insulin clearance during the OGTT was calculated as AUCC-Peptide 0-120 AUCC-Peptide 0-120 AUCC-Peptide 0-120
