Sentence examples for modulate insulin release from inspiring English sources

Our results suggest that islet-originated CAs directly modulate insulin release in a paracrine manner.

Downregulation of PGC-1α in human islets using silencing RNA (siRNA) In order to test whether inhibition of PPARGC1A expression could directly modulate insulin release, isolated human islets were transfected with PPARGC1A siRNA by using Arrest-In Transfection (Open Biosystem; Celbio, Pero, Italy).

However, the molecular mechanisms through which CDKAL1 modulates insulin release in pancreatic β cells are unknown.

Cyclic activation of voltage-gated potassium channels (Kv) generates an outward, 'delayed rectifier' potassium current, which drives the repolarizing phase of each spike and modulates insulin release.

Observation of responses to GLP-1R agonists in isolated blood vessels and hearts suggests that GLP-1 agonists act directly on these target organs and not by modulating insulin release or systemic glucose concentrations, which are controlled in these experiments.

Furthermore, GLP-1 peptides are not only effective in modulating insulin-release and achieving glycaemic control in type 2 diabetes, but are also effective in modulating synaptic plasticity.

The GABA released within the islets normally activates GABAA channels and the GABAB receptor, which modulate insulin and glucagon release.

As shown in Fig. 1, one potential mechanism of how visceral adiposity and inflammatory response modulate insulin sensitivity involves the release of free fatty acids.

In pithed rats, only the initial phase of insulin release was modulated by Conk-S1, suggesting that later changes in glucose levels depended on peripheral, but insulin-independent, regulatory mechanisms.

Cellular studies in vertebrates suggest that InsP3-mediated Ca2+ release modulates pancreatic β-cell function and insulin release (Dyachok and Gylfe, 2004).

Additionally, the systemic administration of OEA has been found to modulate glucose homeostasis, as well as both insulin release (Ropero et al., 2009) and insulin signalling in both hepatocytes and adipocytes (González-Yanes et al., 2005; Martinez de Ubago et al., 2009).