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Raw data of microarray experiment is provided in Table S5.

Third, the sample size used in the microarray experiment is small.

The variation in gene expression evident from this microarray experiment is very complex.

As a result, the microarray experiment is projected on a much smaller list of statistically significantly changed gene sets which can summarize the observed expressional changes on a gene-systems level.

For each disease, a set of candidate genes (e.g., from a linkage study) has to be defined and a relevant microarray experiment is required (e.g., diseased sample vs. reference sample).

However, often the sample size for each individual microarray experiment is small.

Each microarray experiment was performed in duplicate.

Microarray experiment was commercially done by Agilant Genotypic Technology, Bangalore, India.

The microarray experiment was carried out as described [46] with minor modifications.

A microarray experiment was performed using the Maize Oligonucleotide Array (www.maizearray.org).org

Whole transcript microarray experiment was performed.