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As only small amount of sample can be obtained from the SN regions of treated mice, we turned to analyze p62 degradation in response to 6-OHDA treatments in cultured cells.
As we failed to observe relevant changes in PIDDosome-defective premalignant mice, we turned our focus back on diseased mice.
To address the significance of the crypt fission data and to infer the fission rate in WT and K-ras mice, we turned to a more quantitative analysis.
DOI: http://dx.doi.org/10.7554/eLife.07539.004 To circumvent the neonatal lethality of Ddb1 f/f::Vav1Cre+ mice, we turned to the Mx1Cre strain that can be induced to delete the target gene.
Given the lack of a motor behavioral phenotype in young adult Lrsam1 mutant mice, we turned to more detailed analyses in older mice, including an examination of neuromuscular junction (NMJ) morphology at 5 months and at >12 months of age to look for signs of die-back neuropathy (Fig. 4).
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When mice are on the run, we have time to think of how to kill them better; when we are overrun by mice, we turn to cats, prayers, and hope.
"If," Kahn said, "we could figure out the gene [differences] between these two mice we could turn on and off diabetes and metabolic syndrome".
In the absence of ChIP-seq data in E18.5 mouse fetal lung, we turned to a motif-based analysis of the relationship between NFIB binding and gene expression.
As avian ICAM-1 is not available and DT40 cells do not adhere to human or mouse ICAM-1, we turned to an aggregation assay to assess LFA-1 function in these cells.
Having established that Meis binding to the Hoxa2 proximal promoter is conserved from mouse to zebrafish, we turned to the zebrafish embryo model to examine the effects of Meis knockdown on Hoxa2 expression.
To assess the gene expression patterns during embryogenesis, we turned to mouse, where expression data are abundant from all developmental stages.
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