Sentence examples for metabolic dysfunction including from inspiring English sources

Additionally, alteration of the gut microbiome leads to changes in the bile-acid pool, which affects the farnesoid X receptor (FXR) nuclear antagonist involved in the regulation of bile acid, as well as lipid and glucose metabolism (Li et al., 2013), and could cause metabolic dysfunction, including obesity and insulin resistance.

Intriguingly, both lead to metabolic dysfunction including insulin resistance and type 2 diabetes.

In the postpartum period, this should be followed by energetic attempts to prevent them progressing to frank obesity and related metabolic dysfunction, including the potentially devastating risks of diabetes and cardiovascular disease.

Lastly, many of the complications of metabolic dysfunction including nephropathy, neuropathy, and cardiac dysfunction cannot be successfully replicated in single genetic mouse models of metabolic dysfunction or in high fat-fed rodents [ 18].

For instance, bioenergetic metabolism plays a pivotal role in the replication of viruses, and the targeting of metabolism by viral proteins can translate into clinical symptoms, best exemplified by chronic hepatitis C, which is characterized by metabolic dysfunction, including insulin resistance.

Recent evidence squarely positions prostatic diseases as sequelae of systemic metabolic dysfunction, including hyperinsulinemia, hyperglycemia and hypercholesterolemia; however, the underlying etiologies of such susceptibilities remain unknown largely because of the absence of a molecular understanding of the basic metabolic machinery governing prostatic function.

Comprehensive treatment methods for hyperandrogenism and glucose and lipid metabolic dysfunction include lifestyle modifications, diuretic medicines, insulin-sensitising and anticholesteremic agents and oral contraceptives (OC).

Metabolic syndrome is a cluster of metabolic dysfunctions, including central obesity, hypertension, glucose, and lipid abnormalities.

HAART may lead to increase in metabolic dysfunctions, including insulin resistance, diabetes, dyslipidemia, lipodystrophic and cardiovascular diseases, 6, 14– 16 hypercholesterolemia, low levels of high-density lipoprotein cholesterol (HDL-C), hypertriglyceridemia, lactic acidemia, and hypercoagulopathy.

We report that the xav mutation causes a loss of ETFDH function and defective electron transfer, and that both xav and fibroblasts from a phenotypically severe MADD patient have similar metabolic defects and mitochondrial dysfunction, including altered energy metabolism, dysregulated ROS production and altered expression of genes critical for mitochondrial function.

The occurrence of organ dysfunction, including acute respiratory distress syndrome, renal dysfunction, metabolic acidosis, and hematologic dysfunction, based on biomarker levels is shown in Figure 5.