Sentence examples for metabolic reprogramming including from inspiring English sources

Second, there is extensive evidence that demonstrates the existence of each component of the metabolic reprogramming, including aerobic glycolysis, pentose phosphate pathway up-regulation and tricarboxylic acid cycle down-regulation [16].

CRC typically show characteristic tumour phenotypic alterations, which are manifestations of genetic changes and metabolic reprogramming, including sustained angiogenesis, limitless replication potential, and altered metabolic pathways (including an increased glycolytic capacity) [5].

Metabolic reprogramming, including aerobic glycolysis, de novo lipid biosynthesis and glutamine-dependent anaplerosis, fuels cancer cell growth and proliferation (DeBerardinis et al., 2008).

The resulting pseudohypoxic phenotype in ccRCC tumors leads to massive angiogenesis, as well as an extensive metabolic reprogramming, including a shift from mitochondrial oxidative phosphorylation to non-oxygen-requiring glycolysis.

A major distinction, however, is that elicitation of a biotic defense response is associated with a second prolonged oxidative burst of high intensity, which in turn triggers massive transcriptional and metabolic reprogramming, including high level induction of defense protein expression, slowing of growth, and, in the most extreme cases, induced cell death [ 23, 24, 26- 29].

The transcriptomic and metabolic reprogramming lead to a shift in C/N metabolism including induction of enzymes involved in GABA shunt – an important link between C/N metabolism and accumulation of GABA, that could be toxic to the feeding maggots, along with the concomitant release of reactive oxygen species, such as singlet oxygen, that trigger HR in the host.

This subsequently enhances ER-mitochondria coupling and mitochondrial metabolic reprogramming which includes increased mitochondrial ROS production, calcium signal, membrane potential, and mass.

Taken together, this suggests that initial events in WNT5A-mediated changes to melanoma cell behaviour result in their metabolic reprogramming, which includes increased LDH expression and activity.

Metabolic reprogramming in cancer cells facilitates growth and proliferation.

Reduced expression of the tumor suppressor protein TP53 can also impact metabolic reprogramming in cancer cells.

In conclusion, Hcy promotes T-cell activation by increasing ER-mitochondria coupling and regulating metabolic reprogramming.