Sentence examples for mediating repression of from inspiring English sources

The vein patterning defects may result from the role of Gro in mediating repression of pro-vein genes by E spl), a target of the Notch signal, while the blistering may result from improperly coordinated growth of the dorsal and ventral epithelia that comprise the wing.

In animals, miRNAs are thought to regulate gene expression by mediating repression of protein synthesis and/or destabilization of mRNAs [5], although recent studies have indicated that in the majority of reported cases, a reduction in protein synthesis can be explained by direct down-regulation of target mRNA levels [6], [7].

Concerning to the process mediating repression of CDH1 gene expression by LOXL2i, we favored the hypothesis that LOXL2 could act on Snail1 through two overlapped and concurrent mechanism.

To the best of our knowledge, this finding identifies a previously unreported role of PTP1B and PTEN as molecular links mediating repression of IGF-1 signalling at high superoxide anion concentrations in the mammalian system (Fig 9).

Recent studies have identified a role for ROS in mediating repression of Sp proteins and the nitro-NSAID GT-094 and curcumin induce ROS-dependent downregulation of Sp proteins and Sp-regulated gene products in colon cancer cells [ 25, 40].

However, it is clear that the role of CST is not limited to telomere protection and that both Stn1 and Ten1, like Cdc13, have a role in mediating repression of telomerase activity, as partial loss-of-function alleles of all three proteins cause telomere elongation.

One such modification, the trimethylation of lysine 27 on histone H3 (H3K27me3) is required for Polycomb Repressive Complex 2 (PRC2) mediated repression of a large number of genes essential for cell proliferation, cell differentiation and tumor development [ 22, 23].

Together, this suggests that different site-specific factors are involved in the recruitment of distinct H2A E3 ligases to mediate repression of a specific set of genes.

However, Wnt/β-catenin could also mediate repression of Mstn indirectly, through induction of its direct target follistatin [48] that is a known negative regulator of Mstn [49].

It is unclear at this stage as to how NF-κB mediates repression of some target promoters and activation of others.

To determine if the PrrH RNA was able to mediate repression of these genes in response to heme, the ability of iron and heme to affect their expression was examined by qRT-PCR.