Sentence examples for mediating activation of from inspiring English sources

As IKK α also plays a key role in mediating activation of RelA by inducing phosphorylated-degradation of I κB α, which then activate transcription of pro-inflammatory genes, we examined if RelA pathway was affected by baicalin treatment in TAMs.

The epidermal growth factor receptor (EGFR) dimerization arm is a key feature that stabilizes dimerization of the extracellular receptor, thereby mediating activation of the tyrosine kinase domain.

In the present studies, we tested a novel, bifunctional anti-inflammatory prodrug (NDH 4338) designed to target cyclooxygenase 2 (COX2), an enzyme that generates inflammatory eicosanoids, and acetylcholinesterase, an enzyme mediating activation of cholinergic inflammatory pathways in a model of SM-induced skin injury.

We hypothesized that virulence depends on these tyrosine phosphorylation events mediating activation of p85/p110-type PI3K.

This complex, serves as a scaffold for recruitment of signaling adapters mediating activation of the divergent NF-κB and IRF3 pathways.

The IKKβ is best known for mediating activation of the classical NF-κB cascades by pro-inflammatory cytokines and pathogen-associated molecular patterns (PAMPs) and is instrumental for regulating innate immunity and inflammatory responses [3].

For example, Corona et al.14 administered Tacrolimus, a calcineurin phosphatase inhibitor that reduces macrophage and dendritic cell activity and inhibits interleukin-2 (IL-2) mediated activation of T lymphocytes, in combination with MMGs.

Deng, J. et al. Translational repression mediates activation of nuclear factor κB by phosphorylated translation initiation factor 2.

Because anti-NKG2A revived IFN-γ secreting capability of NK cells (Fig. 3g), we expected that NK might mediate activation of T cell response through IFN-γ.

Inclan YF, Persat A, Greninger A, Von Dollen J, Johnson J, Krogan N, et al. A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa.

The data suggest that a discrete pool of protein kinase C may mediate activation of the respiratory burst in PMN.