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Overall, Pten can be directly linked to the extrinsic apoptotic pathway through mediation of TNFα signaling and the intrinsic apoptotic pathway by mediating expression of mitochondrial apoptosis factors.
Several studies have demonstrated a role for ATF4 in mediating expression of VEGFA in response to various stimuli such as homocysteine [56], arsenite [57], oxidized phospholipids [58], and osteopontin [59].
This study demonstrates a novel role for PROK1 in early pregnancy in mediating expression of CTGF.
Many regulators are involved in mediating expression of these virulence factors.
The p53 tumor suppressor protein is involved in a complicated regulatory network, mediating expression of ~1000 human genes.
These promoter sites have been shown in numerous studies to act as pathogen-responsive cis-elements mediating expression of individual defense-associated genes [ 19].
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Apart from its stimulatory effect on LEE, grlA also mediates expression of non-LEE encoded effectors [25].
To overcome these issues, we describe here a Cre-transgenic line that can mediate expression of multiple Cre-dependent transgenes of choice in very few neurons of the adolescent neocortex, hippocampus, olfactory bulb, striatum, amygdala, hypothalamus and superior colliculus.
We developed three different AAVs: an AAV which mediates expression of a peptide consisting of amino acids 76 121 of CaM, CaM-peptide, along with GFP (AAV-CaM-peptide + GFP), an AAV which mediates expression of a scrambled version of CaM-peptide along with GFP (AAV-scram-CaM-peptide + GFP) and an AAV which mediates expression of only GFP (AAV-GFP).
Upregulation of PR-1 by BR in eds5-1 and npr1-1 backgrounds, as well as in short-term treatment, suggests that BR directly mediates expression of this gene.
NF-κB is an important transcription factor that mediates expression of multiple genes in important biologic processes including cell growth, apoptosis, and transformation [ 30- 32].
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mediating endocytosis of
mediating induction of
mediating folding of
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