Sentence examples for mediate their action from inspiring English sources

It was initially thought that estrogens mediate their action through estrogen receptor α (ESR1).

GCs mediate their action on osteoblasts through BMP.

Statins mediate their action via suppression of Th17 differentiation with the concurrent induction of Treg differentiation.

Thus, although MMP activity is clearly required for invasion, these results suggest that TNC-16 and TNC-14/16 TNC-14/16heir action through mediateependentheirhaction.

Clinically achievable MET doses inhibit NSCLC cell and tumour growth and sensitise them to IR. Metformin and IR mediate their action through an ATM AMPK-dependent pATM AMPK-dependent

Botulinum toxins are taken up by nerve cells through pinocytosis and mediate their action by binding to neuromuscular junctions and preventing acetylcholine release leading to muscular paralysis (16).

A number of hormonal ligands and/or the nuclear receptors that mediate their actions have been targeted for prostate cancer therapy.

AT1 antagonists is the most recent drug class of molecules against hypertension and they mediate their actions through blocking detrimental effects of angiotensin II (A-II) when acts on type I (AT1) A-II receptor.

This suggests that XEs mediate their actions via voltage-dependent L-type Ca2+ channels in the plasma membrane.

Natural anticancer compounds have been reported to mediate their actions via several mechanisms such as NFkβ inhibition, apoptosis induction, and effects on microfilament aggregation, antioxidant activity, proteasome inhibition and HSP inhibition [ 55].

These growth factors mediate their actions through activation of two different transmembrane – receptor signaling systems: the Trk receptor tyrosine kinases (TrkA, TrkB, TrkC) and the p75NTR neurotrophin receptor, a member of tumor necrosis factor (TNF) receptor superfamily [ 3, 4].