Moreover, the emphasis it placed on estimating average CSR effects in a given setting diverted attention from the heterogeneity of these effects and the conditions that mediated their impact, limiting its external validity.
Platelet secretion is undoubtedly of pivotal importance for regulating not only canonical platelet functions, but also mediating their impact on other cells, and understanding platelet secretion may have consequences reaching far beyond the 'platelet field'.
Behaviour change was heavily influenced by peoples' first-hand experience of AIDS deaths, backed up by prevention programmes, with interpersonal communication playing a key role in mediating their impacts on behaviour (Halperin et al., 2011; Muchini et al., 2011).
The totality of the evidence for these loci therefore indicates that their effect on HDL-C is primarily mediated by their impact on HDL particle size.
The data also indicated that the anabolic effects of bortezomib and PIs may have been mediated by their impact on the osteocytes rather than on osteoblasts.
Our present findings suggest that such genetic influence on individual differences in perceptual switch rate might be mediated by their impact on the development and maturation of the SPL.
Our work has further clarified the way in which these factors impact on an individual's QoL, as illustrated in Figure 2. It appears that the impact of personal and social, NHS response (treatment) and disease state factors on QoL are mediated by their impact on a person's emotional, physical and social functioning.
Through their metabolic activities, microbial populations mediate the impact of high gradient regions on ecological function and productivity of the highly dynamic Columbia River coastal margin (CRCM).
Specifically, social affiliation with Taiwanese (assimilation) and Americans (accommodation) during their second semester of study was hypothesized to mediate the impact of pre-departure personality on functional adjustment and emotional well-being in the third semester, controlling for acculturative stressors encountered in the first semester.
