Sentence examples for mediate their expression from inspiring English sources

Our data demonstrate that UBF1/2 bind highly active Pol II-transcribed genes and mediate their expression without recruiting Pol I. Furthermore, we reported ChIP-sequencing analysis of UBF1/2 in immortalized human epithelial cells and their isogenically matched transformed counterparts.

These data suggest that embryonic H3K27 tri-methylation at these loci does not mediate their expression or repression.

Other studies have revealed that environmental conditions are very important for cell re-differentiation, and it is well known that the biochemical and physical factors act in concert with genes to mediate their expression [ 20].

SF-1 binds to shared promoter elements upstream of the steroid hydroxylases to mediate their coordinate expression in steroidogenic cells.

Both cell types lack MHC-II expression, primarily mediate their immunosuppressive effects via prostaglandin E2, and displayed a concentration-dependent immunosuppressive effect when added to MLRs [ 14, 26].

This inhibition was partially lost in Megf8 −/− explants, indicating that TG neurons require Megf8 expression to mediate their maximal response to the inhibitory effects of BMP4.

It has been hypothesized that statins mediate their effects by increasing the expression in bone of the growth factor bone morphogenic protein-2 (BMP-2) which in turn leads to osteoblast differentiation and bone formation [ 2].

The mere presence of a high load of plasmid copies or high levels of Yop effector (mediated by their expression from the expression vector) could not account for the observed attenuated phenotype, since the control strain (Kim53pGFP) carrying the same vector load and the YopJ-expressing strain (Kim53ΔJ+J) were highly virulent similar to the wild-type Kim53 strain.

To address whether identified Notch targets were relevant for the overgrowth, we used RNAi to mediate knock down of their expression in Nicd expressing cells (with ptc-Gal4 Gal80ts).

As a major post-transcriptional gene regulator, miRNAs mediate the expression of their target genes in adaptation to environmental stress.

A highly conserved sequence upstream of the transcriptional enhancer in the U3 of murine leukemia viruses (MLVs) was reported to mediate negative regulation of their expression.