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To mediate their entry into the gel, importins must locally perforate the hydrogel.
In any regard, the trimeric envelope glycoprotein (GP) spikes of the filoviruses are believed to mediate their entry into host cells via endocytic pathways.
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LDL receptors, which reside on the surface of liver cells, help to control cholesterol levels in the body by binding to low-density lipoprotein particles circulating in the blood and mediating their entry into the cells (Horton et al., 2009).
Flow cytometric analysis showed that MP-g-OEI copolymers could efficiently mediate the entry of nucleic acids into cells.
The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has two major functions: interacting with the receptor to mediate virus entry and inducing protective immunity.
EBOV preferably utilizes hTIM-1, not other TIM proteins, to mediate the entry efficiently, which suggests that hTIM-1 probably has a direct or indirect interaction with EBOV glycoprotein (GP).
In humans, combinations of CD4 and CXCR4 or CCR5 can mediate cell entry of HIV-1.
CNG channels were proposed to mediate Ca2+ entry in salamander cones hyperpolarized below −40 mV [5], [14].
Binding to an Importin-α molecule in the cytoplasm is often required to mediate nuclear entry of a signaling protein.
CPMV was previously shown to interact with vimentin displayed on cell surfaces to mediate cell entry, but the expression of surface vimentin on APCs has not been characterized.
Citric acid works in a similar manner to acetic acid, inducing the low pH transition in the viral HA protein thus rendering it unable to mediate cell entry.
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