We could identify aggrecan, tenascin and link protein HAPLN1 as PN components essential to mediate their neuroprotective properties.
Many antithyroid drugs and PB mediate their carcinogenic properties by elevating circulating TSH levels in the rat albeit by different mechanisms (Hood et al. 1999; McClain et al. 1988).
In contrast, many endogenous and exogenous compounds (including dietary components) that have been identified as having agonist or reverse-agonist properties also mediate their effects by activating the AhR, yet these compounds do not exhibit toxicity (Zhou et al. 2003).
But according to singularism, not all thoughts about objects are mediated by thoughts about their properties.
CTLA-4 has an important inhibitory function in T cell regulation, and is assumed to mediate immunosuppressive properties of human Foxp3+ Treg cells [23].
However, neither activation of NO signaling, nor NO-associated hemodynamic effects mediate cardioprotective properties of EPO.
It would be of interest to readers to show alignment of mouse, intervening species, and humans to narrow in on the changes most likely to mediate these properties.
Prolactin family members such as proliferin and prolactin could mediate proangiogenic properties of the FGF/STAT5A activating axis through autocrine mechanism [ 88].
In insect classical conditioning, octopamine (the invertebrate counterpart of noradrenaline) or dopamine has been suggested to mediate reinforcing properties of appetitive or aversive unconditioned stimulus, respectively.
Moreover, all of these compounds display weak to extremely weak muscarinic receptor binding affinity, indicating that as potential antidepressants, they may overcome certain side effects that are of concern with other antidepressants, which are thought to be mediated by their anticholinergic properties.
