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Cell-cell contact may trigger intracellular signaling pathways such as the β-catenin pathway [21].
These observations suggest that Env expression alone, in the absence of HIV-1 viral replication, may trigger intracellular antiviral surveillance which acts to partially restrict the maximal expression of Env gp140.
However, there is growing evidence to support the premise that glycoproteins on the surface of virus particles may trigger intracellular signalling pathways by interacting with their cognate receptors on the host cell membrane [1].
The ability of some lupus sera/plasma to induce DC differentiation has been attributed, at least in part, to the presence of IFNα and/or immune complexes within SLE sera that may trigger intracellular toll-like receptors TLRs) and stimulate increased IFNα expression [38].
Given the known signalling capability of NEP, a close homologue of ECE-1, it can be speculated that heterodimerisation of ECE-1 isoforms may trigger intracellular signalling.
Similar(54)
Although the link between reduced phospholamban expression and altered cardiac contractile function in APP/PS1 hearts is unclear, reduced phospholamban levels may trigger altered intracellular Ca2+ homeostasis en route to affect cardiomyocyte contractile function [18].
Necrotrophic pathogens for instance, may trigger the intracellular production of ROS during the killing of host tissues.
This may occur via the adhesive function of P-selectin and its potential capacity to trigger intracellular signaling.
Of particular, R149Q is unable to trigger intracellular signaling and behaves as a competitive inhibitor [29].
CYT1/CYT2 intracellular domains have been demonstrated to differentially trigger intracellular signaling upon further Her4 activation by γ-secretase [ 19, 20].
These further activate other downstream effectors to trigger intracellular processes [ 11].
Related(20)
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