Sentence examples for may activate intracellular from inspiring English sources

As a result of uPA, uPAR and cathepsin B, interactions with certain proteins may activate intracellular signaling molecules such as focal adhesion kinase (FAK).

Elevated MRP4 and PGT expression, particularly in epithelial glandular cells, may result in increased availability of PGE2 and PGF2 α, which through engagement of their EP3, EP4, or FP receptors (also elevated in endometriosis) may activate intracellular signals such as the diacylglycerol or cyclic AMP pathways.

The present data indicate that the extracellular interaction by L1-CAM in injured neurons may activate intracellular signaling cascades such as p38 MAPK and affect the neuroplastic changes in the DRGs and spinal dorsal horn, resulting in the pain hypersensitivity in neuropathic conditions.

Both bacterial components such as lipopolysaccharide (LPS), and proinflammatory cytokines such as interleukin (IL -1β, IL -1βand tumor necrosis factor (TNF)-α, resulting from the immune response to sepsis, mandactumore inecrosisular mechanisms associated with insulin resistance, such as the IKKβ/Nfactorand JNK paTNF -α.

Released lipids may then activate intracellular and membrane-associated receptors, and thus act as second messengers, transmitters and hormones.

This finding suggests that surgical stimuli may rapidly activate intracellular pathways leading to secretion of HMGB1, which is subsequently spilled out into the circulatory stream.

However, neutrophils are capable to interact with A549 cells via binding of CD11/CD18 to ICAM-1 [ 36, 37], and ligation of ICAM-1 on A549 cells may directly activate intracellular signaling pathways (e.g., the MAP kinases ERK and JNK) with subsequent induction of cellular proliferation [ 38, 39].

In addition, the aqueous components of the staining reagents may contain or activate intracellular RNAases and result in RNA degradation.

Alternatively, other integrins may be able to mediate adhesion to fibronectin, but integrin β1 may be required to activate intracellular molecules that mediate cell spreading.

This result suggests that there are different cellular responses to varying HP magnitudes; for example, it can be speculated that increasing HP from 5 MPa to 10 MPa in the presence of TGF-β1 may activate additional intracellular pathways that lead to enhanced production of ECM proteins and increased biomechanical properties.

These differences may help to explain the differing effects on cellular behaviors of binding to these ECM ligands, as fibronectin and PDGF-BB may act in unison to activate intracellular signaling cascades that converge in MAPK activation, while laminin-5 may not.