These experiments revealed that in the presence of PNU-120596 and 10 µM choline, low densities of expression of CA1 pyramidal α7* nAChRs generate persistent step-like currents which cause transient depolarizations and occasionally, may trigger bursts of action potentials (Figure 5).
The observation that bilirubin may trigger suicidal erythrocyte death reveals a potential vicious cycle, as death of erythrocytes is followed by heme degradation with formation of bilirubin.
However, for a series of earthquake events affecting regions marked by a relatively arid climate or during dry seasons (with CB < 1), the landslide triggering potential may also be reduced; we estimate that this was the case for the recent 2015 Nepal, the 2011 Tohoku or the 2003 Altai events, among others.
If many individuals with headache are not aware of common risk factors which may trigger their headache episodes, raising awareness to these potential triggers may reduce the burden of headache in the population.
The remaining 345 potential candidate products (around 98%) may trigger more detailed comparative assessments, at least of the agronomic aspects, and where appropriate also of the safety aspects.
Local elastase production by activated neutrophils may trigger cortisol release by CBG cleavage, providing a potential mechanism for targeted delivery of corticosteroids to inflamed tissues.
The management of cardiac toxicities may vary among patients and may depend on the drug that has been used, potential existing co-morbidities and concomitant medications that may trigger cardiac events.
A large mainshock may trigger numerous aftershocks within a short period, and large aftershocks have the potential to cause additional cumulative damage to structures.
