Sentence examples for may promote aberrant from inspiring English sources

In Brca1-deficient cells, Moynahan et al [ 12] believe that nonhomologous processes may promote aberrant types of repair.

Loss of miR-145 and miR-133a, both of which are endogenous FSCN1 inhibitors, may promote aberrant expression of FSCN1 contributing to pathogenesis and progression of BC.

In addition, loss of miR-145, which is an endogenous Fascin-1 inhibitor, may promote aberrant expression of Fascin-1, increasing its abundance and contributing to the invasive and viability properties of CRC.

Especially in long-lived animals, somatic genome instability can lead to the accumulation of genetic insults that may promote aberrant cellular behavior, ultimately leading to lethal diseases such as cancer.

While TNFα, IL-1β, transforming growth factor beta, and chemokines (including CCL17, CCL22, CCL2, and CCL3) contribute to the recruitment of inflammatory cells, the altered balance between angiogenic chemokines (CXCL5, CXCL8, and CXCL12) and angiostatic chemokines (CXCL9, CXCL10, and CXCL11) may promote aberrant angiogenesis/fibrosis.

Interestingly, expression of LS-associated SHP2 mutants with impaired catalytic activity in cells strongly enhances the EGF-induced interaction between Gab1 and p85 [ 161], which suggests that these mutant proteins, while acting in dominant negative fashion on the Ras/ERK pathway, may promote aberrant PI3K activation by protecting the p85 recruitment sites against SHP2wt.

In HIV-1 infected individuals, higher levels of IL-10 can blunt both the host T-cell response to HIV-1 and viral replication in macrophages and dendritic cells, as well as promote aberrant dendritic cell activity that may favor the virus [33], [34], [35].

While isolated adipocytes show an increased inflammatory gene expression profile [14], increased infiltration and activation of non-fat cells, such as macrophages, may propagate local inflammation in adipose tissue [13], [15] and promote aberrant extracellular matrix remodeling [16].

Similarly, ethylene can promote aberrant divisions in the shoot [57].

Overproduction of IL-1 is believed to promote aberrant inflammatory response in CAPS patients.

The dysregulated WNT signaling can enhance niche independence and promote aberrant proliferation of stem cells.