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Candidate genes in these two causal regions may implicate aberrant glutamate signalling interacting with epigenetic factors in some ASD cases.
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Genetic associations implicate aberrant activation and regulation of autoreactive T-cells as central to RA.
These data strongly implicate aberrant production of BLC in the formation of these structures.
Altogether, these data clearly implicate aberrant EGFR signaling in the pathogenesis of chordoma.
Finally, NOD2 mutations may decrease the expression of the regulatory cytokine IL-10 in dendritic cells at least, which may implicate NOD2 in disordered regulation of inflammatory cytokines, such as TNF, IL-12 and suppressor T cells, and allow for an aberrant inflammatory response [ 136].
Increasing evidence convincingly implicates aberrant expression of cell cycle regulators in multiple cancers.
Numerous studies have implicated aberrant methylation in the etiology of common human diseases.
Although there is evidence implicating aberrant telomere biology in the etiology of HL [ 32- 35], the prevalence of aberrant sister chromatid cohesion in HL has never been examined.
Recent evidence implicates aberrant NET formation, as well as impaired clearance of NET material, in lupus pathogenesis [ 65, 67- 69].
These observations suggest that aberrant NETosis may be implicated in the pathogenesis of AASV.
Further functional analysis of the mutated CEP63 protein may reveal aberrant cellular functions and implicate the centrosome as an important cellular structure in the biology underlying developmental dyslexia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com