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In addition, the tumour cells may have aberrant differentiations, including neuronal, astrocytic and ependymal lines.
APP processing involves the activation of several Ca2+-dependent proteins and therefore it is likely that increased or decreased Ca2+ levels may have aberrant effects on APP cleavage.
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Nonetheless, one of the copies may have produced aberrant mRNA causing post-transcriptional gene silencing.
Thus, MICA-A5.1 carriers may have an aberrant immunological surveillance by NK and T cells.
Yet, lung TAFs overexpressed α-SMA compared to CFs, indicating that α-SMA expression is largely SMAD3-independent in TAFs, and revealing that TAFs may have an aberrant activated phenotype.
The dysregulation of Th1 genes in Gata3-KO Th2 cells may be due to the opposing interaction between Tbet and Gata3 [ 34]: Gata3-KO T cells may have an aberrant activity of Tbet, which also explains the possible effect of Gata3-deletion on Th1 differentiation.
In contrast, fixed cell assays may have artifacts that lead to dislocation of constituents, and cancer cells are well known to have aberrant morphologies.
However, some canine MCTs have aberrant KIT localization but lack ITD c-KIT mutations, suggesting that other mutations or other factors may be responsible for aberrant KIT localization in these tumors.
Cancer cells often have aberrant centrosome numbers, and we are investigating the relationship between aberrant centrosome number and the genome instability that is common in cancer cells.
Additionally the question "Do you feel you understand the reason for the consult?" may have allowed for aberrant interpretations by the consulting neurologist.
While in biblical times people may have believed that aberrant behavior was caused by demons or by the work of Satan, we now understand that such conduct is the result of emotional or chemical imbalances, genetic factors or various types of mental illness, not the invasion of a person's body by evil forces.
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