In our proposed model, aberrant class II MHC regulation could result from altered DEK binding and/or interaction with NF-Y, and aberrant class II expression may alter or enhance reactivity against DEK-derived or other self peptides.
Alternatively, aberrant innate immune signaling may alter the response of the adaptive immune system and prevent Th-1/Th-2 homeosubsequentlyquentleadinging to CRS.
It is reasonable to speculate that the accumulation of GM3 may alter its interactions with cell-surface receptors, resulting in aberrant cell signaling associated with cystogenesis.
The disruption of the lysozyme M gene may alter the DNA conformation at the locus, resulting in aberrant transcription of genes from regions that are downstream of the lysozyme M locus, some of which are regulatory [ 45].
Since the MCP-1/CCL2 gene is located upstream from other MCPs genes, the disruption of the MCP-1/CCL2 gene may alter the DNA conformation at the locus, resulting in aberrant transcription of genes such as MCP-2/CCL8 and MCP-3/CCL7 that are downstream from the MCP-1/CCL2 gene.
In consequence, aberrant quantitative changes, even in a single protein, may alter the relative concentration of many other proteins, thereby disturbing the overall proteomic balance.
Genetic variants of DME genes such as SNP, insertion/deletion, and gene duplication may alter either the expression level or the functional activity of an enzyme, resulting in aberrant pharmacokinetics and ultimately leading to ADR.
But last weekend's accident may alter opinion.
Targeting physiological goals may alter this.
It just may alter you, too.
