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In conclusion, we have provided evidence that endogenous metallothionein can modulate the immune response in vivo and that intracellular MT may modulate immune function by regulation of transcription factor activity.
This gene is a member of the transforming growth factor β family and is involved with cartilage and skeletal formation [77], but it may modulate immune responses by decreasing proliferation of B-cells and by inducing apoptosis of activated memory B-cells [78].
We suppose that exposure to LF-MF may modulate immune function so as to inhibit tumor.
ICOS may modulate immune responses by increasing the secretion of IL-10.
Moreover, there is growing evidence that n-3 PUFAs have anti-inflammatory properties and may modulate immune responses [ 12, 13].
The present study is the first published study to demonstrate that OCs may modulate immune function in sea turtles.
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Moreover, several studies suggest that CLRs may also modulate immune reactions through cross-talk with other receptors, especially TLRs.
In addition, proteinaceous adhesins also play important roles in entry to and exit from the vasculature and may also modulate immune responses.
Since n-3 polyunsaturated fatty acids (n-3 PUFAs) may beneficially modulate immune responses in a variety of inflammatory disorders, we investigated the therapeutic role of docosahexaenoic acid (DHA), a single n-3 PUFA, in lung fibrosis.
In addition, it was suggested that miRNA may modulate epithelial immune responses at every step of the innate immune network, including production and release of cytokines/chemokines, expression of adhesion and costimulatory molecules [ 18].
Immune system activation increases cell energy requirements [1]; impaired mitochondrial function and ATP production may modulate the immune response in sepsis.
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