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Statins have anti-inflammatory effects [28,39] and may modulate endothelial function modifying responses to open AAA surgery.
Alternatively, FcγR polymorphisms may modulate endothelial leukocyte ingress, dendritic cell endocytosis and antigen presentation [ 26], or macrophage/natural killer cell effector functions to IgG containing immune complexes, each of which could separately influence the pathogenesis of GCA.
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Calcium and vitamin D may modulate postprandial endothelial function.
Alternatively, C4bp may modulate kidney endothelial cell function in a complement-independent manner.
Thus, the expression patterns of extracellular miRNAs that modulate endothelial function and inflammatory signaling may provide key insights into mechanisms that contribute to endothelial activation and injury in the setting of severe sepsis.
Pathological factors modulate endothelial targeting and uptake of nanocarriers.
Toxins can also modulate the immune response by influencing endothelial biology, and can modulate endothelial function by influencing the response of leukocytes.
IAPs have also been shown to modulate endothelial cell migration.
Fibronectins may play an important role in vascular stroma formation because they have been reported to be an essential for the heart and blood vessel morphogenesis [ 45], to be chemotactic for endothelial cells [ 46], to modulate endothelial response to growth factors [ 47], and to promote the elongation of microvessels during angiogenesis in vitro [ 48].
In addition, Adtrp, Nrpt, E2f8 could also modulate endothelial permeability via interaction with Vegf-b [ 47].
At this regard, some findings suggest that both major and minor olive oil components may modulate inflammation and endothelial activation.
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