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Other mechanisms may modulate TGF-β production in the thymus and thus quantitatively influence tTreg differentiation.
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Therefore, it would be interesting to explore the possible kinase(s) that may modulate TGF-β-induced FoxO3 activation.
Collectively, these results indicate that Smad7 deficiency is associated with enhancement of TGF-β signaling in the liver, consistent with the notion that Smad7 is an intracellular inhibitory protein to negatively modulate TGF-β signaling pathway [7].
Moreover, TGF-β can regulate αv integrin expression in breast epithelial cells and αv integrin can modulate TGF-β receptor expression in dermal fibroblasts [ 19, 20].
Several other factors have also been identified that appear to act in concert with or to modulate TGF-β activity.
Dabovic, B. et al. Bone abnormalities in latent TGF-β binding protein (Ltbp -3-null mice indicate a roLtbp -3-null3 in moduLtbp -3-null bioavailability.
Additional experiments revealed that increased PI3Kα signaling reduces cardiac fibrosis in pathological hypertrophy through modulating TGF-β signaling and miR-21 expression.
We hypothesized that as an endogenous cofactor for Egr-1, Nab2 might be involved in modulating TGF-β responses.
Here, we report an important role of BRCA1 in modulating TGF-β signaling during oxidative stress responses.
(A ) Simplified model of sensory inputs modulating TGF-β and insulin signaling in the regulation of the dauer decision.
The nuclear orphan receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) modulates TGF-β signaling and mesenchymal cell plasticity.
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