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In addition to reducing cholesterol levels, statins may modulate smooth muscle cell proliferation and migration.
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Indirectly IL-13 may modulate AHR by its effects on airway smooth muscle proliferation[ 24] and interactions with the airway epithelium[ 25].
Alternatively, uric acid may modulate the response to NO differently in endothelial vs. vascular smooth muscle cells.
IL-13, for instance, may increase bronchoconstriction by directly modulating smooth muscle contractibility and promoting airway hyperreactivity through multiple molecular mechanisms [ 40, 41].
Changes in endogenous circulating concentrations of sex hormones such as testosterone, progesterone, and estrogen may modulate the risk for cardiovascular disease in men and women through direct effects on the vascular endothelium and smooth muscle and indirectly through modulation of blood elements and synthesis of inflammatory and coagulation proteins [ 13- 21].
Therefore, we hypothesized that PHGDH may modulate autophagy in ECSLCs.
In this study, we evaluated to what extend lipids may modulate the MPER immunogenicity.
We hypothesized that PTMs may modulate association of G9a with distinct protein complexes.
Calcium and vitamin D may modulate postprandial endothelial function.
Combining dietary components may modulate many processes involved in ageing.
Cytokines at the local site may modulate exudative PMN apoptosis.
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