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(A) qRT-PCR analysis of miR-33a expression in human breast cancer tissue samples and their matched normal breast tissues from 23 breast cancer patients.
These subtype-dependent, infrequently methylated loci (designated SD-InfreqM) were hypomethylated in matched normal breast tissues.
This was observed in some patient matched normal breast tissues, where low levels of methylation (less than 10%%) can be detected for some genes in these matched normal breast tissues (KTH, TM, AD unpublished results).
However SERBP1 expression was slightly higher in three breast carcinomas compared with the matched normal breast specimens.
The TTP/HuR mRNA ratios and their changes between matched normal breast tissues and the tumor tissues were assessed.
These data suggested that Ubc9 was up-regulated in breast cancer tissues compared to matched normal breast tissues.
Similar(13)
High levels of Se, Zn, and Cr elements in breast cancer cases (N = 40) compared to matched normal breasts (N = 40) were suggested as candidate markers for early detection of breast cancer 34.
Furthermore, we compared APC methylation levels in matched normal appearing breast tissue and primary breast tumour.
By comparing the miRNA profiles of primary breast tumours to matched normal adjacent breast tissue, 71 miRNAs were identified as being differentially expressed.
Positive miR-4728-3p expression was detected in 70.7% (29/41) of matched normal adjacent breast tissues, whereas only 35.5% (33/93) breast cancer tissues expressed miR-4728-3p (P<0.001).
In addition, we collected 56 pairs of matched normal and breast cancer tissue samples from patients with breast cancer (age range, 30-86 years).
Related(20)
matched normal mammary
matched normal tissue
matched normal cancer
corresponding normal breast
matched normal mtDNA
matched primary breast
matched human breast
matched normal mucosa
matched healthy breast
matched normal weight
matched normal exome
matched young breast
matched normal lymph
matched normal cell
matched normal patient
matched normal sample
matched clinical breast
matched normal dataset
matched normal tumor
matched normal epithelium
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