In (A, C, and E), the ratios of the β-actin-normalized expression in the tumors relative to the matched normal mucosa were presented in base two logarithm (log2[T/N]).
The ratios of β-actin-normalized expression in the tumors relative to that of the matched normal mucosa were presented in base two logarithm (log2[T/N]).
About 60% of tumors showed PPARG over-expression and 5% of cases showed not significant differences between tumour tissues and the matched normal mucosa.
There was no statistically significant difference between matched normal mucosa and polyps derived from the same cases, or between colonic mucosa from HPS cases and controls (colonic mucosa from cases with normal endoscopic findings and no history of polyps).
Contrary to previous reports [40]; [14], [14] we found that, MGMT and MLH1 were unmethylated (Fig. S1) in both polyps and matched normal mucosa, while there was no significant difference in DNA methylation of IGF2, H19, and WIF1 (Fig. S1) between polyp and disease free tissue.
An additional two patients with adenomatous polyps were studied along with matched normal mucosa.
Both histologic tumour subtypes had higher expression of GSTP1 than the matched normal mucosa.
Colorectal cancer tissue and matched normal mucosa from 23 patients were studied.
In addition, 60 pairs of fresh gastric tumors and their matched normal mucosa were obtained.
Adenoma samples from both FAP and sporadic patients showed increased methylation compared with matched normal mucosa.
In our 2D DIGE study, desmin was found over-expressed in colorectal tumors relative to matched normal mucosa.
