Sentence examples for matched normal mtDNA from inspiring English sources

Any DNA sequence differences between tumor and matched normal mtDNA were scored as somatic mutations.

Sequence variations found in both tumor and matched normal mtDNA but different from that recorded in the GenBank were scored as germline variations.

Furthermore, pairwise comparison between cancer and matched normal mtDNAs from the same individual further minimizes the contamination of NuMTs in the mutation calling.

Any mtDNA sequences that differed between tumour and matched normal tissue mtDNA were scored as a somatic mutation.

Fifty samples of primary endometrial carcinomas and their matched normal controls were studied to determine whether mtDNA mutations could be identified.

We extracted the mtDNA sequences from 704 whole-genome and 971 whole-exome sequencing data generated on primary cancers and compared them with mtDNA sequences from their matched normal samples.

In order to address some of these questions we undertook global gene expression analysis of muscle biopsies from MDS patients with mutations in TK2 and compared it with that of patients with mtDNA large deletions and aged matched normal muscle.

Sequencing of 'screen-detected' mtDNA abnormalities in the cell lines alongside matched normal DNA demonstrated that around half of the abnormalities (8 of 17) were common to both samples and represented mtDNA polymorphisms.

Cell line matched normal DNA was used to precisely characterise 'screen-detected' mtDNA abnormalities.

We did not exclude candidate somatic mutations which overlap with known mtDNA SNPs; instead our algorithm uses sequencing from the matched normal sample to exclude germline polymorphisms.

All the cases had matched normal tissues.