Sentence examples for matched primary breast from inspiring English sources

There are, however, only few studies that compare methylation profiles of metastases with those of the matched primary breast cancer.

A lower expression level of HEXIM1 was detected in metastatic breast cancers when compared with matched primary breast tumors [ 116].

Mass spectrometric analysis has also been performed using 2-DE in two studies with matched primary breast tumour and lymph node metastases.

To further explore their clinical relevance, we performed locus-specific pyrosequencing in an independent set of 22 matched primary breast tumor samples.

Immunohistochemistry (IHC) staining was performed on tissue microarrays (TMAs) constructed from recurrence breast tumors (n = 59) and matched primary breast tumors (n = 59).

Immunohistochemical staining was performed on tissue microarrays constructed using recurrence breast tumor tissues (n = 59) versus matched primary breast tumor tissues (n = 59).

To address this, future studies should determine AXL expression in sets of matched primary and metastatic breast tumors.

Interestingly, prior evaluation of matched primary and metastatic breast tumors identified the most prevalent gene expression difference as enrichment for ECM molecules in the metastases, comprising some 18% of differentially expressed genes (Weigelt et al., 2005).

Recently, Gaedcke et al. [ 43] reported a de novo protein expression of EGFR in the brain metastases of matched primary and metastatic breast cancer cases, and mouse models have shown the EGFR ligand HBEGF to be one of the key mediators of cancer-cell passage through the blood-brain barrier [ 5].

In a study of genomic profiling of 249 (134 ER-positive and 115 ER-negative) tumor specimens from 208 patients, Jeselsohn and colleagues carried out DNA sequencing of 3,230 exons of 182 cancer-related genes and 37 introns of 14 commonly fused genes, including in 37 pairs of matched primary and metastatic breast tumors [ 30].

Herein, we report the preliminary results obtained from our real-time expression profiling of normal-matched primary breast tumors for six genes, three of which were previously reported [ 1].