Sentence examples for many epigenetic changes from inspiring English sources

With the emerging technologies, one could measure many epigenetic changes (Chapter 5) in humans at all hierarchical levels of biological organization, and monitor their progress during development and growth more accurately than we could ever attempt to do previously.

We envisage that the impaired energy metabolism observed in sepsis [ 10] could drive many epigenetic changes.

But it is also clear that many epigenetic changes are triggered by genetic mutations, especially transposon movements, in the vicinity.

Interestingly, a recent study showed that human retinoblastomas contain many epigenetic changes, such as histone modifications and DNA methylation, at the genomic loci of genes involved in multiple signaling pathways (Zhang et al. 2012).

There are several plausible explanations for this observation: Age-related susceptibility: The epigenome of the developing embryo and fetus is thought to be particularly susceptible to environmental exposures because many epigenetic changes are occurring along with rapid cell division (Perera and Herbstman 2011).

Although the female gamete is blocked at the dictyate stage of the first meiotic prophase during the whole folliculogenesis, many important epigenetic changes occur to organise the genome to attend early embryonic development.

31 Cancer pathologies have been associated to many different epigenetic changes.

It is also possible that some, or even many, disease-specific epigenetic changes occur at tissue-specific sites [ 10].

The asymmetric cell fate resulting from these divisions is likely determined by many factors, such as epigenetic changes and signaling, which we are only just beginning to identify.

Most tumors arise from multiple genetic and epigenetic changes, many of which are difficult to measure in vivo in experimental animals or humans.

Furthermore, many studies suggest that epigenetic changes are involved in the earliest phases of tumorigenesis, and that they may predispose stem/progenitor cells to subsequent genetic and epigenetic changes involved in tumor promotion [ 6].