Sentence examples for multiple epigenetic changes from inspiring English sources

That promise lies in the ability of HDACis to effect multiple epigenetic changes in aberrant cells.

Functional pathway analysis revealed that multiple epigenetic changes were identified within several broad, all-encompassing biological pathways.

Shift toward a Th2 phenotype may result from chromatin remodeling brought about by multiple, coordinated epigenetic changes on genes regulating Th differentiation (Ho 2010).

The transformation of normal breast epithelial cells to metastatic cancer is the result of multiple epigenetic and genetic changes, leading to deregulated interactions with the microenvironment [2].

CRC arises through the accumulation of multiple genetic and epigenetic changes.

Lung carcinogenesis is a multi-phase process involving the accumulation of multiple genetic and epigenetic changes.

Primary tumors generally arise as a consequence of multiple mutations and epigenetic changes affecting key genes that ultimately affect proliferation and survival.

Most tumors arise from multiple genetic and epigenetic changes, many of which are difficult to measure in vivo in experimental animals or humans.

Despite the proliferative phenotype in the airways of TG mice, the expression of hK14 had limited impact on tumorigenesis, which requires the accumulation of multiple genetic and epigenetic changes probably to occur with the increasing age (28).

The development of multidrug resistance not only reflects multiple genetic and epigenetic changes that occur inside cells under cytotoxic conditions, but is also a normal physiologic response of cells in their struggle for survival.

Dietary ITCs and their metabolites act via multiple mechanisms, including epigenetic changes at the level of DNA methylation and histone modifications., Histone deacetylase (HDAC) activity and chromatin remodeling affect DNA damage and repair pathways.