Sentence examples for many epigenetic modifiers from inspiring English sources

This is supported by the fact that many epigenetic modifiers utilize metabolites as cofactors or substrates for their enzymatic reactions.

The aberrant epigenetic patterns can be corrected by treatments with "epigenetic modifiers" or "epigenetic modifying agents" [ 77] that are in clinical trials of various phases [ 76].

In addition, among the genes with dosage effect, transcription factors and epigenetic modifiers could further modulate mRNA expression of their many downstream genes [ 12].

As discussed earlier, the maternal exposure to epigenetic modifiers can affect the transmission of epigenetically controlled traits.

Genome-wide and exomic sequencing data from recent years have demonstrated that mutations in epigenetic modifiers comprise a large portion of all genetic events in many cancers, including tumors such as renal carcinoma, adenoid cystic carcinoma (ACC), and transitional cell carcinoma (TCC) of the bladder (Dalgliesh et al., 2010; Gui et al., 2011; Ho et al., 2013).

Mutations in epigenetic modifiers comprise a large proportion of all genetic events in many cancers.

Interestingly, miRNAs can themselves act as epigenetic modifiers by the post-transcriptional regulation of chromatin modifying enzymes [38].

Because many factors including T-DNA copy number, insertion site, local features, and differential settings of epigenetic modifiers may influence transgene activity, comparisons of chromatin patterns between different loci may be difficult.

Nevertheless, epigenetic modifiers rely on cofactors to generate epigenetic marks.

Oncogenic activating mutations are now known to occur in a number of epigenetic modifiers (i.e. IDH1/2, EZH2, DNMT3A), pinpointing epigenetic pathways that are involved in tumorigenesis.

However, corticosteroids are untargeted epigenetic modifiers and targeted manipulation of epigenetic signatures in a cell-specific and timely manner is what one would like to achieve.