Sentence examples for extensive epigenetic changes from inspiring English sources

Induction of pluripotency by reprogramming factors is accompanied by extensive epigenetic changes in the reprogramming factor recipient cells [ 4– 7].

A growing body of evidence documents extensive epigenetic changes as a result of in vitro plant tissue culture [ 1].

In the decade-long evolution of carcinoma in situ (CIS) toward invasion, extensive epigenetic changes are required for epithelial to mesenchymal transition (EMT) 8 before invasion and metastasis.

The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions.

The correlation between some imprinting methylation in tumour and normal tissue means that cfDNA originating from tumours could also potentially be used for this type of work but there is an extensive epigenetic change in tumours, and cfDNA may not always be relevant to investigations of cancer-predisposing epigenetic change in normal tissues.

It has been well established that the evolution of polyploid genomes is an extremely dynamic process compared to that of diploids, characterized by extensive genetic and epigenetic changes occurring in the nuclear genome following polyploidization [ 1- 3].

Tumors are distinguished by extensive epigenetic deregulation, of which changes in DNA methylation are best characterized.

Because fetal development is a period of extensive cellular replication and growth, epigenetic changes may establish long-term patterns among exposed individuals [ 22- 24].

In this study, we performed comprehensive epigenomic and transcriptomic profiling during the critical stages of spermatogenesis using chromatin immunoprecipitation sequencing (ChIP-seq) and RNA-seq, and demonstrate that global epigenetic changes underlie extensive transcriptional alterations during spermatogenesis.

It is expected that there is extensive crosstalk between categories and because epigenetic changes are often regulatory events and can lead to altered gene expression, they can impact other hallmarks of aging, such as by silencing of DNA repair genes or anti-inflammatory genes.

Since the pathophysiology of obesity is concomitant with extensive gene expression changes, special emphasis is put on identification epigenetic changes induced by obesity and mechanism through which epigenetics contribute to obesity [ 150].