Sentence examples for frequent epigenetic changes from inspiring English sources

Frequent epigenetic changes in malignant neoplasias are global hypomethylation and focal hypermethylation of multiple CpG island gene regulatory regions.

The evolution will result from branched genetic evolution within the tumor [ 134] as well as even more frequent epigenetic changes [ 161– 161].

Combining the results of the current study with previous investigations, frequent epigenetic changes (⩾20%) in RCC include promoter methylation of RASSF1A, TIMP3, DAPK, SLIT2, MT1G and GSTP1 (Esteller et al, 2001a; Nojima et al, 2001, Dreijerink et al, 2001; Morrissey et al, 2001, Morris et al, 2003).

Recently, we reported frequent CASP8 (43%) and RASSF1A (56%) promoter methylation in Wilms' tumours and the present study has demonstrated that SLIT2 methylation represents a further frequent epigenetic change in Wilms' tumours.

Recently, accumulating data reveal that O-GlcNAcylation is frequently related to epigenetic changes.

Aberrant gene transcriptions resulting from epigenetic changes are frequent events in the molecular pathogenesis of malignant transformation.

The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions.

It has been suggested that epigenetic changes are more frequent in cancer cells than genetic mutations [ 1].

Epigenetic changes frequently accompany genomic changes during tumor progression.

Genetic or epigenetic changes of BLU are frequent in NPC [ 6- 8].

Polyploidy, more frequent in plants than animals, may trigger genetic and epigenetic changes (Adams and Wendel 2005) of the genomes leading to constant genome restructuration and reprogramming.