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Larval FHM were exposed to seven concentrations of each of four pyrethroids (permethrin, cypermethrin, esfenvalerate and bifenthrin) in order to establish dose response curves.
Likewise, future experiments should use a range of doses of DCS to establish dose dependency.
To establish dose linearity and proportionality, dose-normalized AUC0 ∞ and half-life were analyzed using regression analysis (α = 0.05).
Doxorubicin was purchased from Sigma-Aldrich and dissolved in phosphate-buffered saline (PBS) at various concentrations to establish dose responses.
Initial screening to establish dose ranges revealed that both models are sensitive to gemcitabine with tumor inhibition at doses greater than 40 mg/kg.
Trials are designed to determine proof-of-concept (POC) and to rigorously establish dose selection that will enhance the likelihood of success in the confirmatory phase.
Similar(52)
Two groups of subjects were considered in order to establish dose-responsive effect of HD on fertility.
Identification of cancer risks often begins with case reports that prompt formal epidemiologic studies to establish dose-response relations, which are required for risk assessment and ultimately, for disease prevention.
The two objectives were, first, to establish dose-response observations in tumor and non-target tissue and, second, to evaluate the accuracy of tumor 99mTc MAA SPECT/CT predictive dosimetry [6] in direct Gy-to-Gy comparison to post-radioembolization doses by 90Y PET.
However, the elucidation of the molecular complexity of PL products and the identification of both the essential growth factors that determine the fate of a specific stem cell and the criteria to establish dosing require further investigation.
We used FLIPR (Molecular Devices) to screen the function of TAS2R9 and to establish dose-response curves for the tested compounds (Supplementary data, Table S1).
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