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The current review extends this effort by examining how the application of motor learning principles, such as training specificity, setting, dose, duration, and intensity, may impact the efficacy of dual-task interventions.
Suberoylanilide hydroxamic acid (SAHA) is an oral HDAC inhibitor that has demonstrated some anti-tumor activity in the phase I setting; dose limiting toxicities included dehydration, anorexia and diarrhea [ 65].
Screening-type assessments may be appropriate for priority setting, dose setting, chemical ranking, and so forth.
In the metastatic setting, dose reduction is often instituted after development of febrile neutropenia to minimize future complications.
In the sequential setting, dose to the surrounding breast tissue is unwanted, and in case of SIB, dose to the surrounding breast tissue is necessary.
In this setting, dose adjustment of HSS is critical for preventing potential side effects of severe acute hypernatremia (osmotic demyelination syndrome or central pontine myelinolysis [ 16], renal failure [ 17], phlebitis [ 13]).
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Although the MTD should be determined using different administration schedules and routes, the MTD that we determined in the present study can be a helpful guide in setting doses of anti-cancer drugs in further chemotherapeutic tests with KAD rats.
Operators should liaise with local radiation protection advisors in order to set dose reference levels for CTOs.
73 While treatment with a set dose of 60 mg of obatoclax mesylate over 24 hours every 2 weeks was well-tolerated and several patients maintained stable disease, no PR or CR was observed.
Although they backed its biggest drug hope, cholesterol fighter Crestor, analysts fear they will set dosing restrictions which could limit its appeal.
The efficacy data were used to set doses for the 6-day repeat dose side effect study in rats.
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