Sentence examples for defining dose from inspiring English sources

The reasons include (a) the animal model fails us, (b) the Phase 2 trials are ineffective in defining dose, and (c) the Phase 3 trials are poorly done.

To examine the differences in MSTN-, GDF11- or activin A-inhibitory capacity of these proteins, IC50 (ligand concentration inhibiting 50%% of MSTN, GDF11 or activin A activity) values were estimated using a non-linear regression model defining dose response curve.

Radiological imaging plays an important role in oncological trials to provide imaging biomarkers for disease staging, stratifying patients, defining dose setting, and evaluating the safety and efficacy of new candidate drugs and innovative treatment.

Defining dose recommendations in these patients requires larger studies.

This is the most conservative way of defining dose escalation for glargine in order to reduce potential bias towards exenatide.

All these aspects impact the technical difficulties to routinely monitor, measure and characterize NMs in workplace settings principally related to the lack of easy to use instruments as well as to the difficulty in defining dose metric parameters, other than traditional mass, which may better reflect the NM biologically effective dose in the nano-toxicological field [ 102, 105, 106].

Maximum initial gentamicin doses ranged from 450mg to 600mg and 5 ICUs had no maximum defined dose.

This is where dosimetry, or more specifically the tools used to define dose, will have significant value.

Therefore, NHPs infected with a defined dose and strain of Mtb, are ideal for the study of TB granulomas.

High-dose NSAID is more than the daily defined dose.

Oral challenge is performed using a defined dose of Salmonella Typhi suspended in sodium bicarbonate solution.