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Mice were given a previously established dose of oral corticosteroids [21] one hour prior to viral infection and daily thereafter.
By tracking intracellular calcium concentration, we established dose response curves of receptor activation following PTC administration to cells that have been previously transfected with DNA for wild-type and mutant hTAS2R38.
We demonstrated with a previously established dose [24] that pioglitazone-fed room air control animals had significantly attenuated (p = 0.021) total numbers of inflammatory cells in the BAL following infection compared to vehicle-fed mice (Figure 5A).
Thereby, we hypothesized that the complexes are much more tolerated in direct comparison to cisplatin and decided to compare a well established dose of cisplatin in the murine model with different doses of the compounds.
Mice were treated with a previously established dose [24] of 60 mg/kg pioglitazone (Toronto Research Chemicals, Toronto, Canada), suspended in 100 µL of PBS, via oral gavage beginning on day 2 of smoke-exposure and daily thereafter.
Patients received monthly injections of lanreotide Autogel® at their established dose.
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TIP peptide inhalation currently lacks an established dose-effect correlation in vivo.
Donepezil was chosen for characterising the forgiveness in the in silico analysis due to the following reasons: (i) most widely used acetylcholinesterase inhibitor, (ii) high number of MEMS data available (2720 monitored days), and (iii) an available PK as well as PD model and an established dose-response relationship.
Interspecific allometric scaling can provide a tool for calculating drug doses for animals that lack established doses, based on established doses for domestic animals or humans.
All in vitro and in vivo doses were calculated from established doses in the current literature.
Weekly administration of doxorubicin was based on established dosing regimens (Yoneda et al, 1999; Dubois et al, 2002).
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