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However, the elucidation of the molecular complexity of PL products and the identification of both the essential growth factors that determine the fate of a specific stem cell and the criteria to establish dosing require further investigation.
A phase I trial undertaken to establish dosing for phase II concluded that a single dose up to 15 mg kg 1 is sufficient to break peripheral tolerance.
During the phase I study, the vector is injected into individual joints of subjects with RA to establish dosing and safety.
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Two groups of subjects were considered in order to establish dose-responsive effect of HD on fertility.
Larval FHM were exposed to seven concentrations of each of four pyrethroids (permethrin, cypermethrin, esfenvalerate and bifenthrin) in order to establish dose response curves.
Identification of cancer risks often begins with case reports that prompt formal epidemiologic studies to establish dose-response relations, which are required for risk assessment and ultimately, for disease prevention.
We used FLIPR (Molecular Devices) to screen the function of TAS2R9 and to establish dose-response curves for the tested compounds (Supplementary data, Table S1).
Common practice is to attempt to establish "doses without effect".
Likewise, future experiments should use a range of doses of DCS to establish dose dependency.
Tier 2 testing involves long-term assays to establish such interactions, explore more complicated endpoints, and establish dose-response relationships.
To establish dose linearity and proportionality, dose-normalized AUC0 ∞ and half-life were analyzed using regression analysis (α = 0.05).
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