Sentence examples for cta expression from inspiring English sources

In order to determine whether DNA methylation could account for the heterogeneous expression of CTA in MM, RT PCR analysis of CTA expression was performed on total RNA from MPP-89, MES-MM98, MES-OC99, MES-1, and MES-2 MM cells, treated with the DNA hypomethylating agent 5-AZA-CdR and compared with untreated controls.

Studies correlating CTA expression with clinicopathological features in different tumor types have demonstrated the association of CTA positivity with higher tumor grade, advanced stage or metastatic disease and worse clinical outcome [ 13, 17- 25].

While there is evidence to suggest that promoter demethylation might be a major driver of derepression of CTA expression in cancer [ 3], this mechanism does not appear to be universally applicable to all CTAs [ 34].

Epigenetic events, particularly DNA methylation, appear to be the primary mechanism regulating CTA expression in both normal and transformed cells, as well as in cancer stem cells.

The pharmacologic modulation of CTA expression profiles on neoplastic cells by DNA hypomethylating drugs will also be discussed as a feasible approach to design new combination therapies potentially able to improve the clinical efficacy of currently adopted CTA-based immunotherapeutic regimens in cancer patients.

We found CTA expression in 21.1% of our cHL series.

Therefore, our results emphasize the importance of studying CTAs expression in a Brazilian set of patients.

Although this is rectified with the use of the cTA, gene expression cannot be turned ON by the addition of an inducer in this case.

Another CTA family whose expression pattern was studied in cHL was SSX.

Because of their restricted expression, CTAs are considered relevant to cancer biology and their prognostic relevance has been assessed in the recent years by several studies for various malignancies [ 5, 6].

This observation, however, is likely confined to the reported setting, as the ability of 5-AZA-CdR to induce the expression of CTA, efficiently recognised by CTA-specific CTL, is well characterised both in human and mouse cancer cells (Coral et al, 2002; Sigalotti et al, 2004; Guo et al, 2006).