Your English writing platform
Discover LudwigSuggestions(1)
Exact(4)
These were consistent with the results of ASS and OTC expression.
Consequently, these results suggested that sensitivity of TNBC to rhArg is related to ASS and OTC expression and rhArg might be a potential therapy for TNBC.
As described above, NAGS mRNA is curiously expressed in mouse spleen and testis and also at mouse embryonic day 7, in the absence of significant CPS1 or OTC expression, thus positing another possible function of NAGS or NAG.
Moreover, many ASS-positive cell lines, which were found to be resistant to ADI treatment, were sensitive to rhArg because of the absence of OTC expression in these cells.
Similar(56)
The gene expression of OTC in these cell lines was also determined by quantitative RT-PCR.
We confirmed the tissue-dependent gene expression of Otc, Acsl6, and Ndufs4, the genes carrying downstream hypo T-DMRs for liver, brain, and heart, respectively, by using real-time PCR.
The result indicated that A549 cells expressed OTC gene and A375 cells did not express OTC as reported previously, whereas Raji and Daudi cells did not express OTC.
The expression of native OTC in control cells did not affect mitochondrial integrity.
These results were in agreement with the above-mentioned conclusion that OtrC expression efficiently affects OTC production in S. rimosus.
To further characterize the mechanism of decreased enzyme activity, CPS1 and OTC were quantified for protein expression differences (Fig. 4B).
Gelatin zymographies and ELISA analysis of OTC conditioned media revealed enhanced expression of pro- and active- MMP-2 with increasing GM-CSF overexpression (Fig. 3D and E unicolored columns; SI. 2A).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com