Sentence examples for binding of various ligands from inspiring English sources

Here we analyze and investigate the factors responsible for recognition and different conformational changes accompanying the binding of various ligands to OASS.

The size of the pocket allows for binding of various ligands at this position in various orientations (see Supplemental Material, Figure S5).

Numerous pathways that promote cell proliferation are activated by the binding of various ligands to cell surface receptor tyrosine kinases (RTKs).

By manipulating these parameters, the mechanosensitive binding of various ligands to fibronectin and the subsequent cellular response has been studied in a controlled manner [13,15,36].

For reasons mentioned in the Introduction, the manually pulled fibronectin fibers serve as a model system to study the mechanosensitive binding of various ligands to fibronectin.

The low-density lipoprotein receptor-related protein 1 (LRP1) is a large receptor whose extracellular domain mediates the binding of various ligands associated with the ECM, and cooperation between LRP1 and ITGB2 was reported to mediate cell adhesion in leukocytes [ 24].

> > -wrap-foot> Plactivationisatinitiateditiated upon binding of various ligand molecules to their cognate cell surface receptors, which trigger intracellular signalling cascades that lead to shape change, release of granule contents, thromboxane A2 (TXA2) synthesis and release and thrombus formation (Gibbins, 2004).

The main advantages of using molecular docking methodology are to analyse the binding modes of the ligand with the target, compare binding energies of various ligands, and estimate stability of docked ligand-target complexes.

If the structural properties of the receptor site are known (for example, there is crystallographic data) then techniques involving approximations of potential functions can be applied to estimate or at least compare binding affinities of various ligands [1].

Our results demonstrate that (i) the energetic of the key water molecule are more favorable for the binding site in the Cathepsin B protein (ii) Water bridging and triangle formation were seen between the key amino acid residue and the ligand (iii) The internal energy is significant factor for the binding modes of various ligands.

Surface plasma resonance (SPR) was then used to evaluate the affinity, selectivity, and binding mode of various ligands with the immobilized G-quadruplex complexes of various topologies, 86) as a means for screening viable drug targets.