Sentence examples for binding of exogenous ligands from inspiring English sources

The binding of exogenous ligands displaces the distal histidine and induces a conformational rearrangement involving the reorganization of internal void volumes.

Pro107 is critical for maintaining the proper structure of the distal pocket of the high-spin heme of MauG, controlling the binding of exogenous ligands to the heme iron and directing the reactivity of the heme-activated oxygen during catalysis.

Mirroring the procedure of our first approach, we evaluated the fraction of genes to exhibit AHR binding in the absence of exogenous ligands (p < 0.05).

In the absence of exogenous ligands, Cygb takes up its original structure by binding Fe to the endogenous ligand, HisE7.

Addition of exogenous ligands increased PTHrP transcript levels up to 10-fold by 6 h.

The I119E variant showed altered properties of exogenous ligand binding and redox behavior in the wild type DcrH-Hr (WT).

Interestingly, binding sites for the ETS family of transcription factors were found near regions of chromatin occupied by PPARβ/δ in either the presence or absence of exogenous ligand, whereas binding sites for the CREB/ATF/AP1 family of transcription factors were more commonly found in regions of chromatin occupied by PPARβ/δ only in the presence of ligand.

For example, the ETS binding sites were commonly present near the PPRE of genes that were modulated in the presence or absence of exogenous ligand, whereas the CREB/ATF/AP1 binding sites were commonly present near the PPRE of genes that were modulated only in the presence of exogenous ligand.

Our goal was to examine the extent to which a de novo evolved protein, originally selected on the basis of ligand binding affinity, could be evolved to remain stably folded in the absence of exogenous ligand.

Higher cross-linker concentrations and incubation at higher temperatures (37 degrees C) allowed detection of EGFRwt dimers even in the absence of exogenous ligand.

In the presence of exogenous ligand, the occupancy of PPARβ/δ observed for type III response genes was predominant near the TSS but there was a shift in binding towards the region upstream of the TSS compared to the occupancy of PPARβ/δ observed without exogenous ligand.