Sentence examples for binding of small ligands from inspiring English sources

Internal cavities in proteins produce conformational fluctuations and enable the binding of small ligands.

These commonly involve large interacting surfaces that present no well-defined pockets or grooves for high-energy binding of small ligands.

Introduction: The molecular mechanics energies combined with the Poisson Boltzmann or generalized Born and surface area continuum solvation (MM/PBSA and MM/GBSA) methods are popular approaches to estimate the free energy of the binding of small ligands to biological macromolecules.

In contrast, binding of smaller ligands such as glycerol is penalized by the fewer favorable interactions, which cannot overcome the unfavorable entropy of binding (loss of translational and rotational freedom) at room temperature.

Computational methods to predict binding affinities of small ligands toward relevant biological (off- targets are helpful in prioff- targetse screening are synthelpfulf new drug candinates, thereby sprioritizinghe drug discovery process.

The microtubular surface displays a surprisingly large number of binding sites, with numerous proteins binding to the outside surface and a multitude of small ligands binding to the inside of microtubules [ 11].

It was suggested that this amino acid regulates the migration of small ligands in rice Hb1, for example in ligand binding to the Fe-heme, ligand migration through internal docking sites and ligand release into the external solvent.

On the other hand, I would like to see a discussion of RRM and other analogous folds at the end of the manuscript, when it could serve a more useful purpose of establishing some trends in evolution (do we see lots of small ligand-binding domains evolving from nucleic-acid binding domains? How about the other way around? And so on).

The results of this work further understanding of small ligand binding to proteins in general, and their role in the allosteric regulation of the PKA in particular.

We concluded from this set of experiments that lack of small ligand binding or catalysis disrupts not only Edc3 localization to P-bodies but also the accumulation of other P-body components, which is consistent with previous work showing that Edc3 plays an important assembly role for yeast P-bodies (Decker et al. 2007).

Conformational changes across the entire molecule have been elucidated in response to the binding of small molecule ligands and show a pattern of mobility consistent with postulated signal transduction modes between the nucleotide binding domain (NBD) and the substrate binding domain (SBD).