Sentence examples for be a downstream mediator from inspiring English sources

An association between endometrial cancer and the polymorphism at codon 31 (AGC/serine to AGA/arginine [Ser31Arg]) of the p21 gene, which is known to be a downstream mediator of p53, has also been reported.

CCN2 is induced by both TGFβ and ET-1 and is considered to be a downstream mediator of these proteins [ 12].

GRB7 has been implicated to be a downstream mediator of integrin FAK signal pathways in the regulation of cell migration [ 27], whereas recent studies have suggested that GRB10 and GRB14 play important roles in cell proliferation [ 38, 39].

In fact, like deletion of TOR1, deletion of SCH9 extends yeast CLS in a respiration-dependent fashion, suggesting that Sch9p could be a downstream mediator of TOR-dependent mitochondrial OXPHOS regulation in this regard.

CTGF is a member of the CCN protein family (including Cyr61 (CTGF), CCN2 (CCN2) and Nov) and believed to be a downstream mediator of transforming growth factor (TGF -α acTGF -α 12].

Rho kinase is a downstream mediator of RhoA, and is believed to play a critical role in mediating the effects of RhoA on stress fiber formation, smooth muscle contraction, cell adhesion, membrane ruffling, and cell motility.

It probably suggests that NF-kB is a downstream mediator of the GSK-3 signaling cascade.

Regulation of GAG synthesis by TG2 appears independent of TGF-β activity, which is a downstream mediator of the TG2 functions in some biological systems.

These results clearly implied that TG2 is a downstream mediator of TGF-β-induced EMT.

Moreover, our data suggest that TG2 is a downstream mediator of tumor growth factor-beta (TGF-β -induced EMTGF-β -induced

Moreover, p57Kip2 over-expression experiment indicates that p57Kip2 is a downstream mediator of sik1, acting specifically in the cardiac differentiation process.