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PbGDPS, a key enzyme in the monoterpene biosynthesis (Hsiao et al. 2008), was the only one structural gene containing EEs, suggesting that it might be a downstream gene of circadian clock pathway.
Moreover, both calcineurin-deleted and Crz1p-deleted cells showed lower caspase activity compared to the wild-type cells, indicating that CaMCA1 might be a downstream gene which is blocked in calcineurin-deleted or Crz1p-deleted cells (Fig. 5).
In that report, ZEB2 was shown to be a downstream gene of both a primary transcriptional transducer GLI1 in Hh signaling and of another EMT regulator, TWIST1, and that ZEB2 further up-regulated 5 chemokine or growth factor receptors, PDGFRA, EDNRA, CXCR4, VEGFR2, and TRKB (Figure S4).
They concluded that CPA4 appeared to be a downstream gene in response to the hyperacetylating activity of histones.
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We conclude that LMP1 is a downstream gene of TGF-β1, involved in PDL cell proliferation.
These results suggest that SIX2 is a downstream gene for SIX1 and may not be sufficient for LGE-like cell differentiation even together with PAX6 and FOXC1.
A recent study revealed that p16 is a downstream gene of FOXA1 and leads to a decline of nucleosome density in aging cell p16 gene promoter region, and thus promoting the transcriptional activation of FOXA1 to p16 (Li et al., 2013).
HEY1 is a downstream gene of Notch1 in the Notch pathway.
ERdj4, which is a chaperone protein localized in the ER, is a downstream gene of XBP1, while GADD34 is downstream gene of eIF2α.
This lead-SNP is a downstream gene variant (a sequence variant located 3' of a gene) of ERGIC1 (endoplasmic reticulum-Golgi intermediate compartment protein 1).
We would expect to find C05D2.3 transcripts trans-spliced to SL2 if it is a downstream gene in an operon with bas-1.
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