Sentence examples for be a downstream modulator from inspiring English sources

Finally, since TNFα can be a downstream modulator of Tat's effects [104], it is possible that TNFα, rather than Tat directly, is the molecule responsible for inducing the RelA serine 276 phosphorylation that we observed in Tat-treated microglia.

Taken together, these results suggested that Rac1, but not AKT/mTOR or Rho, is a downstream modulator of PI3K and an essential factor in the bFGF-induced motility of ESFT cells.

Whereas depletion of sortilin, an upstream modulator of hexosamine biosynthesis, inhibits SG and PB assembly, depletion of O-GlcNAc transferase, a downstream modulator of hexosamine biosynthesis, inhibits oxidative stress-induced SG, but not PB, assembly [18].

Importantly, LY294002 inhibited Rac1 activation upon bFGF stimulation, indicating that Rac1 acts as a downstream modulator of the FGFR/PI3K pathway.

S6K is a downstream target of rapamycin (mTOR) pathway, a key modulator of aging [ 75].

ApLRRTK-ΔK acted as a negative modulator of the 5-HT-induced synaptic strengthening (Fig.  4a), suggesting that ApLRRTK is a downstream molecular player of 5-HT-induced synaptic strengthening.

These data suggest that CAST may be a negative modulator of BMD and a downstream target of BMP2 in modulating CAST mRNA expression of osteoblasts.

The Akt/mTOR pathway is another dominant downstream modulator of PI3K, and the Akt/mTOR pathway is involved in IGF-1-induced cell motility and cytoskeletal alterations in ESFT cells (Liu et al, 2008).

Therefore, MUC4 appears to be a modulator of cell proliferation.

We find MECP2 to be a modulator of social aggression.

TGF-β may be an upstream modulator of miR-92a [36].