Sentence examples for be a downstream effector from inspiring English sources

Because our data indicate that enz acts cell autonomously, enz would be predicted to be a downstream effector if it acts in such a hormonal signaling pathway.

However, Ynd1 may not be a downstream effector of the E4orf4-Cdc55 complex in yeast, since Cdc55 and Ynd1 deletions confer additive resistance to E4orf4.

RhoC has been reported to be a downstream effector of Notch receptor [ 115].

We thus propose RhoC to be a downstream effector of Notch1 in cervical tumour progression.

Maspin is known to be upregulated by tamoxifen and is considered to be a downstream effector for the tumor suppression activity of tamoxifen [ 66- 68].

As FOXA1 may also be a downstream effector of GATA-3, it may be a bridge between GATA-3 and ER pathways [ 22], controlling and regulating the biology of luminal mammary cells, breast cancer progression and behaviour.

The above results taken together suggest that PRR5L is a downstream effector of mTORC2.

Caspase 3 is a downstream effector caspase important in death receptor apoptotic mechanisms.

In particular, CEBPB is a downstream effector of the LH signaling pathway in granulosa cells [8].

PAK1 activation is very crucial in cell migration and is a downstream effector of CXCR2 signaling pathway [35].

These observations suggest that WOX1 is a downstream effector of C1q-mediated apoptosis, without involvement of complement activation.