Sentence examples for based on somatic mutations from inspiring English sources

Lineage analysis based on somatic mutations enables performing high resolution reconstruction of lineage trees in mice and humans, which can provide fundamental insights to many aspects of their development and tissue maintenance.

From what has been discussed above, we can envisage that this adaptive character of our immune system may not only have been selected to provide individuals with adaptive responses based on somatic mutations.

Furthermore, many of our horticultural industries are based on somatic mutations: nectarines are a genetic variant of the peach (Prunus persica) and have co-occurred on a single tree since 1937 [ 5].

Pathophysiologically, it is based on somatic mutations of the X-linked phosphatidyl-inositol-glycan gene [ 3, 4] which result in a partial or absolute deficiency of GPI-linked proteins [ 5].

With the exception of high-grade endometrioid carcinomas (HGEC), which appear to overlap in their molecular genetic features with HGSC, the less common histotypes are each distinguishable from HGSC based on somatic mutations occurring in specific genes and gene expression profiles [ 12- 14].

Phylogenetic tree analysis based on somatic mutation and copy number variation was used to study the clonal relationship between different regions of primary and metastatic tumors.

We shall provide additional tools to analyse other types of mutation and to rank genes based on somatic mutation frequencies, aggregated P-values of CHASM or VEST scores, ratios of truncating to non-truncating mutations and counts of recurrently mutated positions.

Thus, we evaluated classifiers based on somatic point mutations only, here used as a collective term for single nucleotide substitutions, short insertions and deletions, and classifiers based on point mutations as well as SCNAs, separately.

In this section, we evaluate the performance of MixClone on both simulated and real datasets and compare its performance with two published algorithms: (i) PyClone, a method based on somatic point mutations, and (ii) THetA, a method based on somatic copy number alterations.

Many of the exercises are based on Somatic Experiencing (SE), many on energy medicine.

Based on the somatic mutations and copy number variation profiles, a phylogenetic tree was generated to explore the evolutionary relationship among tumor samples.